تفاصيل المقرر

المقدمة


All humans are equal, and yet so diverse. We share the same genetic information, with the exception of minute differences; yet we differ in our appearance, character, behavior, and health status. Our knowledge about the genetic bases of health status has rapidly changed over the last few years. The completion of the Human Genome Project provided us with a map of the 3 billion base pairs encoding the blueprint of human life. All physicians in this age of molecular medicine must be well versed in the core principles of human genetics, which is the science of the mechanisms and principles through which genetic information determines health and disease. The human genome has about 20,600 protein-encoding genes. Those known to cause disorders or traits are described in a database called Online Mendelian Inheritance in Man. Searching for genetic changes and gene variants within a population, questioning the link between genotype and phenotype, probing the meaning of gene–gene and gene–environment interactions, investigating the role of somatic mutations in the formation of tumors, exploring the possibilities for prenatal diagnostics, and surveying the gene therapy for directed treatment strategies and preventative medicine are relevant for all fields of medicine.



المحتويات


1. Genetics in Medicine (Medical genetics, Clinical genetics, and molecular Medicine)
2. Cell division (mitosis, meiosis, chromosome segregation, crossing over, genotypes and phenotypes, Mendelian genetics)
3. Types of genetic diseases (Single gene disorders, Chromosome abnormalities, Multi- factorial traits)
4. Genetic markers
5. Linkage and mapping
6. DNA extraction from blood
7. DNA diagnosis (Techniques for analysis, PCR based (conventional and real time)- RFLP, SSCP, Hybridization assays, sequencing, microarrays and other applications)
8. Biochemical basis of genetic disease (prenatal diagnosis and counseling)
9. Restriction fragment length polymorphism RFLP
10. Genetics and immunity
11. Genetics and cancer
12. Recombinant DNA technology, and gene therapy
13. Genetic-environmental interaction (genetic susceptibility to diseases, and pharmacogenetics)
14. Ethical issues in medical genetics



المنسقون



المطلوبات


BIOCHEMISTRY


الأهداف


1) General Objective:
To know the basics of genetics

2) Specific Objectives:
By the end of this course the student should be able to:
2.1 Describe basic genetic concepts and principles.
2.2 Explain how genetic information is passed through generations .
2.3 Determine the traits that individuals exhibits
2.4 Describe the role that genes and environment play in development, Evolution and population biology .
2.5 Discuss the role of genetics in disease
2.6 Know forensics and human ancestry
2.7 Know the basic concepts of recombinant DNA technology, and genetic engineering.



طرق التدريس


1. Lectures.
2. Lab. Experiments
3. Videos
4. Self Learning



المصادر


1) Human Resources:
1.1. Specialists in genetics and biochemistry
1.2. Technicians

2) Physical Resources:
2.1. Library
2.2. Lab. for 250 students
2.3 Lecture room for 250 students



وسائل التقويم


1 A & P --- 10%
2 OSPE --- 20%
3 MCQs --- 40%
4 Short essays --- 30%



المراجع


1 Online Mendelian Inheritance in Man, National Center for Biotechnology Information http://www.ncbi.nlm.nih.gov/omim).
2 HUMAN GENETICS: CONCEPTS AND APPLICATIONS, EIGHTH EDITION (2008). RICKI LEWIS. The McGraw-HILL COMPANIES, Inc.
3 HUMAN GENETICS: FROM MOLECULES TO MEDICINE, FIRST EDITION (2012). CHRISTIAN PATRICK SCHAAF, JOHANNES ZSCHOCKE, & LORRAINE POTOCK. LIPPINCOTT WILLIAMS & WILKINS, A WOLTERS KLUWER BUSINESS.
4 CONCEPTS OF GENETICS, FIRST EDITION (2012). ROBERT J. BROOKER. THE MCGRAW-HILL COMPANIES, Inc.
5 GENETICS A CONCEPTUAL APPROACH, FOURTH EDITION (2012). BENJAMIN A. PIERCE. W. H. FREEMAN AND COMPANY, New York.
6 GENETICS (NATIONAL MEDICAL SERIES FOR INDEPENDENT STUDY), SECOND EDITION (1996). FRED J. DILL, MICAHEL R. HAYDEN, BARBARA C. MCGILLIVRAY, J. M. FRIEDMAN. WILLIAMS & WILKINS A WAVERLY COMPANY.



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